Sparfloxacin - DrugBank
Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, Quinolones differ in chemical structure and mode of action from (beta)-lactam antibiotics. .. Exenatide, The therapeutic efficacy of Exenatide can be increased when ME: Relationship between ciprofloxacin, ofloxacin, levofloxacin. SAR Structure Activity Relationships interferes with essential bacterial enzymes e.g., rifamycins, lipiarmycins, quinolones, and. Cipro, Tablet, film coated, mg/1, Oral, Bayer HealthCare tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, Ciprofloxacin has in vitro activity against a wide range of gram-negative and Locher HH: Structure-activity relationship in the oxazolidinone-quinolone hybrid.
Monocyclic and tricyclic analogs of quinolones: Synthesis, absolute configuration, and antibacterial activity of 6,7-dihydro-5,8-dimethylfluorooxo-1H,5H- benzo[ij]quinolizinecarboxylic acid.
Ciprofloxacin - DrugBank
Difloxacin metabolism and pharmacokinetics in humans after single oral doses. Comparative antibacterial activities of temafloxacin hydrochloride A and two reference fluoroquinolones. Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.
Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli. Recent advances in pharmaceutical chemistry.
J Clin Hosp Pharm. Computer automated structure evaluation of quinolone antibacterial agents. Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydrooxoquinolinecarboxylic acids. Synthesis and antimicrobial activity of 3-formylquinolone derivatives.
Chiral DNA gyrase inhibitors. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro 1-piperazinyl 2'-trans-phenyl-1'-cyclopropyl -1, 4-dihydrooxoquinolinecarboxylic acid.
Asymmetric synthesis and biological activity of the enantiomers of 9-fluoromethyl 4-methylpiperazinyl oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazinecarboxylic acid ofloxacin.
Genetic and physiological characterization of ciprofloxacin resistance in Pseudomonas aeruginosa PAO. In vitro and in vivo activity of DL, a new oxazine derivative.
Mechanism of action of nalidixic acid: Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: In vitro activity of Baya new quinoline derivative, compared with those of other antimicrobial agents. Antagonism of wild-type and resistant Escherichia coli and its DNA gyrase by the tricyclic 4-quinolone analogs ofloxacin and S stereoisomers. Studies on chemotherapeutic agents.
Literature used to divide sulfonamides into anti-bacterial sulfonamides; with an aromatic amine, and non-anti-bacterial sulfonamides; without an aromatic amine. We tried here to collect sulfonamide drugs properties and chemical structures to compare between them from structure differences that reflect on the activities they have. In other words we tried to set Structure-Activity-Relationship SAR from these chemical structures for sulfonamide core.
This helps the researchers more in case they need a reference for these compounds collected in one paper. Sulfonamide common core structure Anti-Bacterial Sulfonamides: In his attempt to save his daughter from streptococci killing infection, he observed that prontosil; a sulfonamide dye, is able to selectively restrain the infectious bacteria cells.Quinolones - Medicinal Chemistry
InErnest Fourneau found out prontosil pathway in human body. He discovered that this dye was a pro-drug. It, actually changes in human body to sulfanilamide which is the anti-bacterial active agent. This invention triggered the discoveries of other anti-bacterial members derived from this chemical group such as sulfapyridine in against pneumonia, and sulfacetamide in against urinary tract infections, and succinoylsulfathiazole in against gastrointestinal tract infections.
On the contrary, sulfanilamide was not very used due to its greater human toxicity.