Relationship between hypercholesterolemia and atherosclerosis

relationship between hypercholesterolemia and atherosclerosis

In general, an inverse relationship is observed between LDLR activity and serum LDL-C level. In other words, lower activity of LDLRs implies. The relationship of hypercholesterolemia to atherosclerosis with particular .. low -density lipoprotein pathway in human fibroblasts: Relation between cell. Cholesterol does not predict degree of atherosclerosis at autopsy Many studies have found an association between LDL‐ or total cholesterol.

relationship between hypercholesterolemia and atherosclerosis

Statins are shown to lower LDL-C levels with high safety, and thus, have been the drug of choice. However, it is difficult to achieve an ideal level of LDL-C with a single statin therapy in the majority of FH patients. Alternatively, lipid lowering combination therapy with the recently-introduced ezetimibe has shown more encouraging results.

Mechanisms of hypercholesterolemia and atherosclerosis.

Hypercholesterolemia, familial; Low density lipoprotein-cholesterol; Hydroxymethyglutanyl-CoA Reductase Inhibitors; Ezetimibe Introduction; Risk of Familial Hypercholesterolemia Familial hypercholesterolemia FHwhich occurs in one in five hundred 0. It is a relatively common genetic disease that induces a rise in low density lipoprotein-cholesterol LDL-C and total cholesterol levels. However, this disease may easily be overlooked clinically. Thirty percent of these patients expired at the time of the first attack of myocardial infarction.

Familial Hypercholesterolemia and the Atherosclerotic Disease

Furthermore, the fact that there is a high possibility of developing cardiovascular disease at young age calls for active clinical concern and vigorous effort. Among these, the most common genetic abnormality is the mutation in the LDLR located on chromosome Their symptoms are atypical, and sudden death is common. Receptor-negative patients may not survive over the age of twenty without proper treatment, while receptor-defective patients are inflicted with clinically significant cardiovascular disease before the age of thirty.

Their serum cholesterol levels and clinical courses are mostly determined by their genetic background. However, uncontrolled risk factors for cardiovascular diseases such as smoking, hypertension and diabetes mellitus increase the risk considerably.

relationship between hypercholesterolemia and atherosclerosis

Clinical features and diagnosis of familial hypercholesterolemia Homozygous FH patients occur very rarely, happening in one in one million people. Most of these patients develop xanthoma before the age of ten.

Familial Hypercholesterolemia and the Atherosclerotic Disease

Unless proper treatment is undertaken as mentioned earlier, most patients expire from cardiovascular disease before reaching adolescence. The human organism gives always absolute priority to the intracellular homeostasis. The naturally occurring balance between both systems can be disturbed: Total genetic absence of malfunction of LDL-receptors is seen in homozygote familial hypercholesterolemia, with ischemic heart disease between ages 2 and Less harmful situations arise from heterozygote familial hypercholesterolemia and from other genetic defects among them those located at the gene of apo E on chromosome 19 and of apo AI on chromosome This has been demonstrated in the rabbit, hamster, dog, baboon and humans.

Overloading the organism with dietary cholesterol and saturated fat is one extremely common factor in western societies. Certain fats omega-6 and omega-3 polyunsaturated, and oleic acid may be beneficial. Other factors are generally of lesser importance. Severe dietary overloading with cholesterol and saturated fat in the rabbit results in early atherosclerotic lesions resembling almost totally those produced by the genetic absence of LDL-receptors Watanabe rabbit.

relationship between hypercholesterolemia and atherosclerosis

In humans from western countries the serum LDL-level is more related to environmental factors, whereas the HDL-level is more related to genetic factors.